Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats.
The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of metabolism, stress resistance and longevity.Apart from its role as an important redox copyright, NAD+ also serves as the sole substrate for NAD-dependent enzymes, including poly(ADP-ribose) polymerase (PARP), an important lotion DNA nick sensor, and NAD-dependen